工作经历、职称、博导或硕导、行政职务

国内外学术任职

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本人的研究方向、研究兴趣

• 卡波氏肉瘤病毒潜伏感染与致瘤的分子机制

作为主持人所承担的课题名称、来源、起止日

[1] 国家自然科学基金青年科学基金项目（81401662）：卡波氏肉瘤病毒（KSHV）编码vIL-6诱导内皮细胞血管生成及其分子机制的研究，2015.1-2017.12
[2] 江苏省自然科学基金青年基金（BK20140908）：KSHV vIL-6 诱导内皮细胞血管生成的分子机制研究，2014.07-2017.6
[3] 南京医科大学科技发展基金（2013NJMU007）：MicroRNAs在HIV-1 Nef蛋白调控KSHV潜伏感染中的作用与意义，2014.01-2015.12
[4] 南京医科大学基础医学院优势学科教师培养基金项目（13JC002）：MicroRNAs在艾滋病毒Nef蛋白调控卡波氏肉瘤病毒潜伏感染中的作用与意义，2015.01-2016.12
[5] 南京医科大学“十二五”第三批教育研究课题青年基金项目（JX222201015）：基于慕课的高校医学微生物学课程建模研究，2015.09-2017.08

代表性科研论文

　[1] Yao S, Hu M, Hao T, Li W, Xue X, Xue M, Zhu X, Zhou F, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling. Nucleic Acids Res. 2015 Oct 7. pii: gkv988. [Epub ahead of print]
[2] Hu M, Wang C, Li W, Lu W, Bai Z, Qin D, Yan Q*, Zhu J, Krueger BJ, Renne R, Gao SJ, Lu C*. A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling. PLoS Pathog. 2015 Sep 24;11(9):e1005171. doi: 10.1371/journal.ppat.1005171.
[3] Fan W, Tang Q, Shen C, Qin D, Lu C, Yan Q*. Preparation and characterization of polyclonal antibody against Kaposi's sarcoma-associated herpesvirus lytic gene encoding RTA. Folia Microbiol (Praha). 2015 Nov;60(6):473-81. doi: 10.1007/s12223-015-0387-x. Epub 2015 Apr 2.
[4] Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, Zhu X, Lu H, Qin D, Yan Q*, Zhu J, Gao SJ, Lu C*. HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res. 2014 Sep;42(15):9862-79. doi: 10.1093/nar/gku583. Epub 2014 Aug 7.
[5] 严沁* MOOC时代的《医学微生物学》课程改革初探 西北医学教育杂志 2015年10月第23卷第5期
[6] 张晓洁，陈菲，郭园园，秦娣，卢春，严沁* 抗卡波济肉瘤相关疱疹病毒vIL-6蛋白合成肽多克隆抗体的制备及初步应用 临床检验杂志 2015年03期
[7] 姚水洪，邱惠萍，刘建军，朱小飞，秦娣，严沁*，卢春 人类免疫缺陷病毒-1负调控因子通过调控糖原合成酶激酶-3β/β连环蛋白信号通路促进人类疱疹病毒8型病毒白细胞介素6诱导血管生成 中华传染病杂志 2014年4期

1. 第一作者论文

[1] Yan Q, Ma X, Shen C, Cao X, Feng N, Qin D, Zeng Y, Zhu J, Gao S, Lu C*. Inhibition of Kaposi’s sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258. J Virol. 2014 May;88(9):4987-5000. doi: 10.1128/JVI.00025-14. Epub 2014 Feb 19.
[2] Yan Q, Li W, Tang Q, Yao S, Lv Z, Feng N, Ma X, Bai Z, Zeng Y, Qin D*, Lu C*. Cellular microRNAs 498 and 320d regulate herpes simplex virus 1 induction of Kaposi’s sarcoma-associated herpesvirus lytic replication by targeting RTA. PLoS One. 2013;8(2):e55832. doi: 10.1371/journal.pone.0055832. Epub 2013 Feb 13.

1. 其他作者位次论文

[1] Xue M, Guo Y, Yan Q, Qin D, Lu C*. Preparation and application of polyclonal antibodiesagainst KSHV v-cyclin. J Biomed Res. 2013 Sep; 27(5):421-9. doi: 10.7555/JBR.27.20120085. Epub 2013 Apr 20.
[4] Zhu X, Guo Y, Yao S, Yan Q, Xue M, Hao T, Zhou F, Zhu J, Qin D, Lu C*. Synergy between Kaposi’s sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. Oncogene, 2013 Apr 22. doi: 10.1038/onc.2013.136.
[5] Qin D, Feng N, Fan W, Ma X, Yan Q, Lv Z, Zeng Y, Zhu J, Lu C*. Activation of PI3K/AKT and ERK MAPK signal pathways is required for the induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1. BMC Microbiol, 2011; 11:240
[6] Tang Q, Qin D, Lv Z, Zhu X, Ma X, Yan Q, Zeng Y, Guo Y, Feng N, Lu C*. Herpes simplex virus type 2 triggers reactivation of Kaposi's sarcoma-associated herpesvirus from latency and collaborates with HIV-1 Tat. PLoS One, 2012; 7(2):e31652